L. reuteri decreases the enrichment of Clostridium sensu stricto 1 and Ruminococcaceae UCG-010 as well as microbiota-derived capric acid, which further inhibits hepatic GALR1-NR1D1-SREBP1 pathway activation and contributes to the amelioration of dyslipidemia. This evidence concerns the gene SREBF1 and metabolic syndrome.