We demonstrated that PTβR2I binds with TβR2 and differentially regulates TGFβ1 pathways: PTβR2I downregulates the TGFβ1/p38 pathway while not affecting the TGFβ1/Smad-2/3 pathway under the hyperglycemia environment in diabetic wounds. This evidence concerns the gene TGFB1 and Hyperglycemia.