It has also been demonstrated that the deletion of autophagy-inducing kinase ULK1 can substantially reduce the growth of xenografted chronic ML (CML) cells, ULK1-mediated inhibition of autophagy followed by enhanced TKI sensitivity was found to be driven by increased mitochondrial respiration and loss of quiescence, and oxidative stress induces leukemia stem cell differentiation and can contribute to the sensitivity of leukemia stem cells to targeted therapies [50]. Here, ULK1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.