The mitochondrial kinetic regulator FIS1 mediates mitophagy in AML and lung cancer cells and depletion of FIS1 can cause attenuation of mitochondrial autophagy and lead to GSK3 inactivation, myeloid differentiation, cell cycle arrest, and severe loss of LSC self-renewal potential [26, 119]. The gene discussed is FIS1; the disease is lung carcinoma.