The IL1RN gene has been found to have variable numbers of an 86 base pair (bp) tandem repeat in intron 2 [42], and this polymorphism is associated with various inflammatory diseases (systemic lupus erythematosus [43], type 2 diabetes mellitus (T2DM) [44]) and ischemic stroke [45]. Here, IL1RN is linked to type 2 diabetes mellitus.