CTHRC1 and myocardial infarction: Ruiz-Villalba and colleagues presented the first scRNA-seq study focusing on cardiac fibroblasts and showed that a subpopulation of the activated fibroblasts, expressing Cthrc1, expanded rapidly in response to myocardial infarction, from 2.3% at the steady state to 12% at 7-day post-injury and to 34% at 14 days, and these cells were exclusively located in the infarct and border zones, presenting a strong pro-fibrotic signature [46].