We found that low levels of m6A/m5C/m1A regulators, including ALKBH5, IGFBP3, DNMT3A, FTO, HNRNPC, METTL3, NSUN4, NSUN5, NSUN6, TRMT6, WTAP, and ZC3H13, indicated a favorable prognosis in colon cancer patients (Fig. 3), while high levels of m6A/m5C/m1A regulators, including NOP2, NSUN2, NSUN7, RBM15B, TET2, TRMT61B, ALYREF, LRPPRC, YTHDC2, and YTHDF1, indicated a favorable prognosis in colon cancer patients (Figure S1). This evidence concerns the gene TRMT61B and malignant colon neoplasm.