KIR3DL1 and infection: Consistent with this is the observation that HLA-B∗58:02, which is disease-susceptible in adult infection, and is Bw4-expressing and, therefore, serves as a ligand for KIR3DL1, does not carry any disease-susceptible effect in children until more than 10 years of age; by contrast, the other two principal disease-susceptible HLA-I in African populations, HLA-B∗18 and HLA-B∗45, which are both Bw6 expressing, have a substantial detrimental impact in the first 10 years of life as well [37▪].