CASP3 and neoplasm: However, 2-DG-induced suppression of cell growth in stem cell-like tumor subpopulations did not correspond with induction of apoptotic cell death, as indicated by a lack of caspase-3/CASP3 activation or downstream proteolytic cleavage of PARP in 2-DG treated CD133/PROM1HIGH patient-derived GBM cells (CASP3 and PARP cleavage were detected using a positive control sample treated with cytotoxic chemotherapy) (Fig. 3b).