While many GBM tumors carry deletions in the p16INK4A/CDKN2A gene [59], here we assessed various markers to measure the induction of senescence following glycolysis/autophagy inhibition, and we found that p21Waf1/Cip1/CDKN1A (which is not frequently lost or mutated in GBM tumors) is upregulated in addition to p16INK4A/CDKN2A. This evidence concerns the gene CDKN1A and glioblastoma.