CDKN2A and glioblastoma: Instead, it was found that glycolysis inhibition in stem cell-like CD133/PROM1HIGH patient-derived GBM cells triggered induction of senescence-related cell cycle arrest, as indicated by significant upregulation in the protein and mRNA expression of p21Waf1/Cip1/CDKN1A and mRNA levels of p16INK4A/CDKN2A (Fig. 3c; Additional file 1: Figure 4B).