Several of these genes, including Ralbp1 [63], Pfas [64], Tyro3 [65], Opcml [66, 67], Syne2 [68], Six4 [69], Tll2 [70], and Slc23a2 [65], were previously implicated in gut microbiome abundance, metabolic traits, and several intestinal diseases. The gene discussed is SIX4; the disease is intestinal disorder.