PYGL and head and neck squamous cell carcinoma: Furthermore, the effect of PYGL on HNSCC’s metastasis and its suppression by cisplatin was examined by determining the metastatic nodules in the lungs 60 days after inoculation, which illustrated that size of pulmonary metastatic nodules was suppressed while cisplatin’s function on metastasis suppression was increased in PYGL knock-down groups (Fig. 5F).