In contrast to tumours with BRCA1 or BRCA2 driver events, which harboured 1.6x (95% CI, 1.0–2.4x) and 1.4x (95% CI, 0.9–1.9x) more SVs as well as excess of 10–100 bp deletions (BRCA1, 2.2x; BRCA2, 7.3x), SPOP tumours did not display excess of other somatic mutation types. The gene discussed is BRCA2; the disease is neoplasm.