In pancreatic neuroendocrine tumours (PanNETs), we discovered four patients with tumours clustering in MuAt feature space to harbour germline mutations in MUTYH (p.Tyr176Cys, two patients; p.Pro292Leu; c.924+3A>C) (Fig. 4f, Additional file 2: Fig. S14) (Additional file 1: Table S8). This evidence concerns the gene MUTYH and neoplasm.