Dual-targeted CAR-T cells co-expressing GPC3 and asialoglycoprotein receptor 1 (ASGR1) exhibited cytotoxicity against GPC3+ASGR1− and GPC3+ASGR1+ HCC cells in vitro and caused a significant reduction of GPC3+ASGR1+ HCC tumor xenografts in vivo [239]. Here, GPC3 is linked to neoplasm.