Recently, Marianna Sabatino et al. conducted a phase 1/2 cohort study (ZUMA-3) in adults with B-ALL to test the safety and clinical efficacy of KTE-X19, an autologous anti-CD19 CAR-T cell product whose manufacturing process enables the elimination of malignant cells [104]. This evidence concerns the gene CD19 and precursor B-cell acute lymphoblastic leukemia.