ERBB2 and breast carcinoma: Additionally, mesothelin-specific CAR-T cells were shown to exhibit increased cytotoxicity towards mesothelin-expressing primary breast cancer cells [195], and human CD3 + T-cells with anti-ERBB2-CAR were found to induce apoptosis in ERBB2-overexpressing breast cancer cells [196], suggesting ERBB2/HER2 as an important target for inducing cytotoxicity in ERBB2-expressing tumors.