Various TCR-based T cell therapies have been in clinical trials: MART1 for treating metastatic melanoma [45], carcinoembryonic antigen (CEA) for treating colorectal cancer [46], NY-ESO-1 and gp100 for treating melanoma [47, 48], and MAGE-A3 for synovial sarcoma treatment [49]. This evidence concerns the gene CEACAM5 and colorectal cancer.