In a phase 1/2 study by Abramson et al. patients with r/r large B-cell lymphomas (including DLBCL, DLBCL transformed from indolent lymphoma, and PMBCL) treated with Lisocabtagene maraleucel (Liso-cel; Breyanzi®), a second-generation anti-CD19 CAR-T cell product, experienced 73% ORR with 53% CR [89]. This evidence concerns the gene CD19 and diffuse large B-cell lymphoma.