Interestingly, two variants associated with low z-insulin in the present study were located on RBFOX1 and SH3RF3, genes that have previously been shown to be related to brain amyloidosis in preclinical Alzheimer’s disease [38] and to late-onset Alzheimer’s disease [39], respectively. This evidence concerns the gene RBFOX1 and early-onset autosomal dominant Alzheimer disease.