CDK4 and melanoma: To study the effects of MEKi and CDK4/6i, 3 NRAS mutant melanoma cell-lines: MELJUSO, SKMEL30 and IPC298 were selected as they showed distinct cellular responses with spindle-shape (MELJUSO), augmented pigmentation (SKMEL30) and typical melanoma morphology (IPC298) phenotypes (Fig. 1).