A dose dependence was also demonstrated by Vanpouille-Box and colleagues in 2017, where a single dose of 20 Gy upregulated three prime repair exonuclease 1 (TREX1) expression, while fractionation of 3 × 8 Gy upregulated ISG expression in patient-derived xenografts of a transcription factor p53 (TP53)- and GTPase K‐Ras (KRAS)-mutated lung adenocarcinoma [44]. Here, KRAS is linked to lung adenocarcinoma.