In line with this observation, an increased AcG/UnG ratio was described for postmenopausal women with insulin-resistance and obesity in comparison to insulin-sensitive controls in a rather small cohort [38] and UnG but not AcG negatively correlated with insulin resistance measured by HOMA index in children with Obesity [39] and adults [30]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.