The number of tumours with both somatic mutations and loss of one or more copy number in TP53 were significantly higher in PRs ESR1HIGH (23%; p = 0.002, Fisher-exact) and PRs ESR1LOW (25%; p = 0.008, Fisher-exact) compared to GRs (9%) (Fig. 8d, Supplementary Fig. 11c). The gene discussed is TP53; the disease is neoplasm.