WNK3 and neoplasm: This is likely due to the lack of lobular tumours in PRs ESR1LOW (3%) compared to GRs (13%) and PRs ESR1HIGH (13%) and also reflected in the percent of somatic mutations in E-cadherin in each group (CDH1 mutations 2% PRs ESR1LOW; 13% GRs and 10% PRs ESR1HIGH) (Supplementary Fig. 8b, c).