MECP2 and post-traumatic stress disorder: Based on this, we recently addressed the potential involvement of altered MECP2 functionality in the onset of PTSD-like pathophysiology in transgenic mice carrying a hypofunctional form of MECP2. We demonstrated that MECP2-mutated mice display an increased propensity to develop enduring neurobehavioral alterations, comparable to those observed in patients with PTSD, when exposed to intense, acute stressors [35].