Previous studies using genetic evidence and MV-MR models17,36,54,55,56 have shown that ApoB, representing the total number of hepatic-derived atherogenic lipoprotein particles, is the most likely causal lipid determinant of CAD, and the evidence for LDL is attenuated toward the null when accounting for ApoB. The gene discussed is APOB; the disease is coronary artery disorder.