Accordingly, SNPs in the TGFB1 gene have been shown to be involved in the susceptibility for DKD due to the role of this gene on tissue fibrosis processes (Buraczynska et al., 2007; Jia et al., 2011; Zhou et al., 2018; Varghese and Kumar, 2019; Zhou et al., 2019). The gene discussed is TGFB1; the disease is diabetic kidney disease.