There are also differences between morphant and stable knockout/knock-in models for some PKD genes, particularly ADPKD models, where morphants typically exhibit more severe phenotypes (body curvature in pkd1a/b morphants and pronephric cysts in pkd2 morphants), potentially because of maternally contributed transcripts.56,60,61. The gene discussed is PKD2; the disease is autosomal dominant polycystic kidney disease.