TNFSF10 and breast carcinoma: Interestingly, siRNA and shRNA-mediated knockdown of FYCO1 also sensitized resistant T47D breast carcinoma cells [17,18] to TNFSF10/TRAIL-induced caspase activation and cell loss (Figure S2D-E), suggesting that FYCO1 neutralization can also sensitize primarily resistant cells to the death ligand.