TNFRSF10A and cancer: Expression of death receptors TNFRSF10A/DR4 and TNFRSF10B/DR5 on the surface of cell membranes is a critical determinant of cancer cell sensitivity to recombinant TNFSF10/TRAIL and to its receptor agonistic antibodies, and their mislocalization in intracellular compartments has been shown to be an important resistance mechanism [53].