Indeed, comparing GSEA pathway analysis among SETD2 differentially expressed genes from TCGA‐KIRC, RPTEC SETD2 KO, and TGF‐β‐regulated genes discussed previously shows that while the TGF‐β signaling pathway is uniquely enriched in TGF‐β‐treated WT RPTEC, many other pathways, including EMT, inflammation, and interferon signaling, are enriched in both the SETD2‐mutant ccRCC samples from KIRC and the SETD2 KO RPTEC model (Fig. 1H). This evidence concerns the gene SETD2 and nonpapillary renal cell carcinoma.