Using RNA‐seq data for these 24 samples, we performed principal component analysis in an unsupervised approach, revealing that SETD2 wild‐type and SETD2 mutant/low tumors largely segregate, and that 1702 genes are differentially expressed between these groups, indicating that SETD2 loss drives a distinct transcriptional signature in primary ccRCC as well (Fig. S3A,B). Here, SETD2 is linked to nonpapillary renal cell carcinoma.