SIX2 and nonpapillary renal cell carcinoma: This result is consistent with enrichment of stemness‐related pathways by GSEA (Fig. 1H) and confirmed by induction of a number stemness genes like CD44, associated with stemness and aggressive ccRCC (Fig. S2C) [39] in SETD2 KO cells, and those relevant to the early mesodermal lineage from which the kidney arises (e.g., SALL1, SIX2, and CITED1, Fig. S4B).