This result is consistent with enrichment of stemness‐related pathways by GSEA (Fig. 1H) and confirmed by induction of a number stemness genes like CD44, associated with stemness and aggressive ccRCC (Fig. S2C) [39] in SETD2 KO cells, and those relevant to the early mesodermal lineage from which the kidney arises (e.g., SALL1, SIX2, and CITED1, Fig. S4B). Here, CD44 is linked to nonpapillary renal cell carcinoma.