Direct comparison of M.tb infected MDMs at pH 7.0 with pH 7.4 (Acidosis (Infected)) demonstrates that acidosis enhances expression of MMPs key to TB immunopathology including MMP-1, MMP-3 and MMP-10 which were increased 5.6, 4.3 and 7 fold respectively (p<0.05). Here, MMP10 is linked to tuberculosis.