Supporting a metabolic shift in M.tb infected human MDMs we found increased expression of multiple glucose uptake (SLC2A1, SLC2A3, SLC2A6), glycolysis (HK2, PFKFB3, ALDOC) and Lactate Dehydrogenase (LDHA, LDHB) genes whilst the “TCA cycle and respiratory electron transport” was the 5th most significantly downregulated gene set by infection. The gene discussed is HK2; the disease is infection.