The NLRP3 inflammasome (comprised of the NOD-, leucine-rich repeat (LRR)-and pyrin domain (PYD)-containing protein 3 (NLRP3), the adapter apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and the effector protease caspase-1) orchestrates Toll-like receptor 4 (TLR4) responses to both sterile and infection-related inflammation. Here, NLRP3 is linked to infection.