Associations with the presence of TERT promoter mutations revealed an overlap of 30 genes in the three bulk RNA-seq cohorts (in melanoma and across entities), of which six genes were consistently up- or down-regulated (up: ARL17A, FBF1, KAZALD1, PRAF2; down: PLEKHB2, RASGRP3; S6 Table). The gene discussed is PLEKHB2; the disease is melanoma.