In this study, we analyzed single-cell sequencing data and high-throughput sequencing data for ischemic stroke, combined with a variety of methods, including dimensionality reduction clustering and weighted co-expression network analysis (WCGNA), and we found that MRPS11 and MRPS12 are robust markers of ischemic stroke, providing reference for its prevention and treatment. The gene discussed is MRPS12; the disease is ischemic stroke.