In the particular instance of lung, breast, and prostate cancer, for example, IL-6 can significantly raise drug resistance by blocking apoptosis via stimulation of Janus kinases (JAK)/signal transducer and activator of transcription 3 (STAT3), phosphatidylinositol-3 kinase (PI3K)/protein kinase B (Akt), and Ras-MAPK pathways. This evidence concerns the gene AKT1 and Familial prostate cancer.