IRAK1 and atherosclerosis: Recently, Hou et al. found that miR-146a-5p overexpression attenuates the inflammatory response in HUVECs induced by lipopolysaccharides (LPS) by suppressing tumor necrosis factor receptor associated 6 (TRAF6) and interleukin-1-receptor-associated kinase 1 (IRAK1), which indicates that miRNA-146a-5p may serve as a potential therapeutic target for atherosclerosis [39].