The present study has identified a positive association between the expression level of YBX3 and the abundance of immune cells such as aDC, pDC, Th1, and Treg cells, suggesting that it would be advantageous to develop treatment strategies that enhance the cancer immunity effect by increasing the infiltration of T cells into tumor tissues (Dora et al. 2021) have also found a close correlation between YBX3 and the tumor immune response. The gene discussed is YBX3; the disease is cancer.