Mutations in genes encoding for tubulin subunits (TUBA1A, TUBB2B, TUBB3, TUBB2A, TUBB5, and TUBG1) have been associated with a broad spectrum of neurodevelopmental disorders, usually transmitted in an autosomal dominant manner and mostly characterized by non-progressive complex brain malformations. This evidence concerns the gene TUBB2A and neurodevelopmental disorder.