Thus, we assessed inflammasome activation by HIV-1 infection or VbP treatment with and without pretreating THP-1 cells with agonists of TLR1/2 (Pam3CSK4), TLR7/8 (CL075), TLR8 (TL8-506), or TLR4 (LPS). The gene discussed is TLR4; the disease is HIV-1 infection.