CASP3 and infection: At 48 h post-infection, ZIKV-TL.PK and ZIKV-p.2.5′ exhibited a significant increase in caspase-3 activity compared to mock-inoculated cells (P < 0.05) but still exhibited a non-significant 25% decrease in caspase-3 activity compared to WT ZIKV-infected cells.