NOD2 and colorectal cancer: When the NOD2 gene is knocked out in mice, it can lead to bacterial overload and inflammatory responses.[79] In addition, deficiency of NLRP6 in mice decreases IL-18 production, so as to increase susceptibility to colorectal cancer,[80] and similar results are also found in NLRP12-deficient mice,[81] implying NLRP6 and NLRP12 play an important role in dysregulation of microbiota and carcinogenesis.