Currently, the known immunotherapy methods for EC include immune checkpoint inhibitors (ICIs), chimeric antigen receptor-T (CAR-T) cell therapy, cancer vaccines, and so on.[11,12] Targeting programmed death-1/programmed death ligand-1 (PD-1/PD-L1) and cytotoxic T lymphocyte antigen-4 ICIs and their clinical trials have been the focus of extensive cancer immunity research. Here, CD274 is linked to cancer.