Equally, to formally conclude these cells are irrelevant for IgE response propagation will require analysis of their abundance relative to type 2 mBC, to determine the order of magnitude by which type 2 mBC outnumber IgE+ mBC as a putative IgE source in different disease states, such as hyper‐IgE, chronic idiopathic urticaria, and allergy. This evidence concerns the gene IGHE and allergic disease.