RHOB and neoplasm: RhoB-depleted cells form tumors more efficiently than cells expressing RhoB when injected intraperitoneally into mice.73 Cells transfected with RhoB and subcutaneously implanted into nude mice suppress tumor growth.74 CNF1-induced activation of Rho GTPases may thereby hinder colon tumorigenesis induced by colibactin-producing E. coli.