The prediction accuracy of the PRS, measured in terms of the AUC, is quite similar between the various methods in a variety of variant selection scenarios (e.g., AUC between 0.70 and 0.73 for schizophrenia (Ni et al., 2021), and between 0.73 and 0.74 for AD with two predictors, APOE and PRS without APOE region, the latter calculated with different methods; see supplemental table 2 in Leonenko et al., 2021). This evidence concerns the gene APOE and Alzheimer disease.