Figure 1 schematically shows the APOE‐e4 allele frequency dynamics in an ageing population, with frequency f = 0.42 in AD cases (age at onset 66.4 ± 7.8 years) and f = 0.16 in population controls (age 66.0 ± 6.5 years), with OR consistently reported as ≈ 3.4 (see e.g., the review by Andrews et al., 2020). The gene discussed is APOE; the disease is Alzheimer disease.