At the protein level, we observed that active beige adipocytes expressed more UCP1 as compared to white or inactive beige adipocytes regardless the FTO rs1421085 genotypes, however, less UCP1 protein amount was detected in obesity-risk than in risk-free allele carrier active beige adipocytes (Figure 3B). Here, UCP1 is linked to obesity due to melanocortin 4 receptor deficiency.