PPARA and obesity due to melanocortin 4 receptor deficiency: Importantly, genes overrepresented in metabolic, especially in energy metabolism-related pathways, such as TCA cycle, lipolysis, pyruvate metabolism, and PPAR signaling were downregulated in active beige adipocytes with obesity-risk genotypes as compared to risk-free allele carriers, indicating lower energy dissipation in active beige adipocytes with CC alleles.