Next, we investigated the gene expression pathways affected by the FTO rs1421085 SNP and found that genes, which were less expressed in active beige adipocytes that carried the obesity-risk genotype, were overrepresented in several pathways, such as metabolic, PPAR signaling, lipolysis, fatty acid metabolism, or TCA cycle (Figures 2E, F). This evidence concerns the gene PPARA and obesity due to melanocortin 4 receptor deficiency.