A total of 175 genes including thermogenic markers (UCP2, CKMT2, and CITED1) and 5 BATLAS markers (PPARGC1B, ACO2, ACSF2, NNAT, and DMRT2) were expressed less in active beige adipocytes carrying FTO obesity-risk variant as compared to risk-free carriers (Figure 2D, top panel; Supplementary Table S5). The gene discussed is DMRT2; the disease is obesity due to melanocortin 4 receptor deficiency.