This is in association with our previous study, which reported that the thermogenically prone human neck derived adipocytes carrying FTO obesity-risk genotype had lower expression of thermogenic genes, such as CKMT1A/B, CITED1, PPARGC1A/B, and CPT1B and genes involved in respiratory electron transport, fatty acid metabolism, and the signaling by retinoic acid pathways (Tóth et al., 2020). This evidence concerns the gene PPARGC1A and obesity due to melanocortin 4 receptor deficiency.