When the gene expression profiles of the three types of adipocytes were analyzed by segregating the FTO rs1421085 risk-free (TT) and obesity-risk (CC) allele carrier samples, intriguingly, we found that the SNP affected the gene expression profile, in particular the expression of thermogenic markers (CITED1, CIDEC, PLIN1, LIPE, CKMT2, and S100b), in active beige adipocytes, but not in white or inactive beige adipocytes. The gene discussed is LIPE; the disease is obesity due to melanocortin 4 receptor deficiency.