In this study, we employed transcriptomic and metabolomic data to investigate the effect of FTO rs1421085 SNP on the thermogenic capacity of three types of adipocytes: white, active and inactive beige, which were derived from human adipose-derived stromal cells (hASCs) isolated from abdominal SC fat of donors carrying FTO risk-free (TT) or obesity-risk (CC) genotypes (4 individuals of each genotype). This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.