In oncogenic Epstein-Barr virus associated with development of Burkitt lymphoma, nasopharyngeal carcinoma, and Hodgkin lymphoma, viral EB2 protein (also called SM, Mta, and BMLF1), a KSHV ORF57 homolog, interacts with the RS domain of SRSF3, and activates a cryptic alternative 5' splice site in intron 23 of STAT1 to produce a dominant negative repressor of STAT1 protein 163. The gene discussed is STAT1; the disease is Hodgkins lymphoma.