Furthermore, in the 4T1-RNase1 BALB/c mice, the addition of compound 1 had no synergistic impact of RNase1 in the antitumor effect (Figure 1B to 1G, red vs. green), suggesting that RNase1 and compound 1 may target a common profile to contribute to the tumor-suppressive function, probably owing to conformational changes upon binding to EphA4 and transmission of EphA4 forward signals into immune cells to unleash antitumor immunity. The gene discussed is EPHA4; the disease is neoplasm.