Together with our flow cytometry data indicating an enriched EphA4+CD3+ T cell population in PBMCs (Figure 6C and S6D), the existence of the RNase1-EphA4 axis on T cells may play a part in upregulating T cell-mediated antitumor activity, which is distinct from the dominant role of this axis in tumor cells as an oncogenic pathway 24. Here, EPHA4 is linked to neoplasm.