RNASE1 and neoplasm: Remarkably, treatment with recombinant RNase1 protein in the coculture system between PBMCs and BT-549-αCD3 rendered tumor cells more sensitive to killing by PBMC-T cells (Figure 5A, line 6 vs. line 4), likely owing to more activated T cells boosted by RNase1, whereas there was no significant difference in levels of apoptotic cells in the presence or absence of RNase1 when PBMC-T cells were not activated (Figure 5A, line 5 vs. line 3).