These results support the previous findings that the RNase1-EphA4-activating axis contributes to breast tumor progression in an immunocompromised mouse model, in which there was no significant difference between 4T1-vector mice and 4T1-vector plus compound 1 mice in tumor volume (Figure S1B, black vs. blue) or weight 24. This evidence concerns the gene RNASE1 and breast neoplasm.