CASP3 and neoplasm: As expected, BT-549 cell clones without PBMC incubation had minimal caspase-3/7 activity (Figure 5A, lines 1 and 2), and coculture of PBMCs with BT-549-αCD3 had a larger PBMC-T cell-killing effect than did coculture of PMBCs with BT-549-Vn (Figure 5A, line 4 vs. line 3), supporting the idea that activated PBMC-T cells have a role in tumor suppression.