As shown in Figure S1A to S1C, consistent with nude mice's tumor weight data 24, we detected a significant induction of tumor volume in nude mice bearing 4T1-RNase1 tumors compared with the mice injected with control tumor cells (red vs. black); the induction was suppressed by the EphA4 inhibitor compound 1, which binds to the ligand-binding domain of EphA4 and EphA2 and inhibits their receptor activation 36 (red vs. green). This evidence concerns the gene EPHA2 and neoplasm.