Together with the results that 4T1-RNase1 tumor samples did not have changes in the frequencies of M1-like and M2-like macrophages, dendritic cells (DCs), and monocytes (Figure 2D, clus_1, _8, _4, and _6, respectively, red vs. black), cells expressing RNase1 favor an antitumor TME, possibly due to the interplay between T and NK cells as well as MDSCs. This evidence concerns the gene RNASE1 and neoplasm.