Our results in immunocompromised nude mice bearing 4T1 breast tumors showed that RNase1 promoted tumor weight 24 and tumor volume (Figure S1) by associating with EphA4, which is distinct from the results of Fischer et al., who found that RNase1 inhibits tumor growth in nude mice bearing HT-29 colon tumors through the reduction of exRNAs-mobilized tumor necrosis factor-α 23. Here, RNASE1 is linked to colonic neoplasm.