After injection of AAV (K46E) or in the sepsis group, the levels of MDA and Fe2+ were significantly increased as compared with the control group, and down-regulation of VDAC2 malonylation by AAV (K46Q) decreased the levels of MDA and Fe2+ of heart tissues in sepsis rats (Figure 2G-H). Here, VDAC2 is linked to Sepsis.