NFE2L2 and chronic myelogenous leukemia, BCR-ABL1 positive: Similarly, other studies also reported that wogonin had strong reversal potency in the ADR-induced resistant human CML K562/A02 cells through inhibition of MRP1, decrease of the binding ability of Nrf2 to ARE and modulation of Nrf2 through reduction of Nrf2 mRNA in transcriptional processes 60.