NFE2L2 and cancer: For instance, the IC50 values of halofuginone in normal epithelial cell lines BEAS-2B and NCC16-P11were 436.3 and 442.7 nM, respectively, while the IC50 values for the Nrf2-addicted cancer cells KYSE70 and A549 were 114.6 and 58.9 nM, respectively.