PTEN and neoplasm: SaRNAs have received much attention in the field of cancer therapy, as they can enhance the transcriptional activation of tumor-suppressor genes such as p21 236, 237, Wt-1 238, E-cadherin 239, NKX3-1 240, and PTEN 241 through various mechanisms 236, 242, 243, by inducing cell-cycle arrest, inhibiting proliferation, inducing apoptosis, inhibiting metastasis, and reversing multidrug resistance 236, 242, 243.