Familial clusters of leukemia led to the identification of germline variants associated with lymphoid neoplasms (PAX5, IKZF1, SH2B3, and ARID2), myeloid neoplasms (RUNX1, GATA2, CEBPA, DDX41, ANKRD26, ETV6, and TP53), and inherited bone marrow syndromes (GATA2, TERC, TERT, FANCA, and FANCB) (31). Here, TP53 is linked to leukemia.