These pathways involve CLU, APH1B, ABCA7, BIN1, PICALM, and MARK4, all of which have been widely proven to be closely related to the pathogenesis of AD by GWAS and numbers experiments (Jansen et al., 2019; Nott et al., 2019; Li et al., 2021; Schwartzentruber et al., 2021). This evidence concerns the gene PICALM and Alzheimer disease.