Some of them have been proven to be contributed to the onset of AD, such as HLA-DRB1, HLA-DQA1, and HLA-DQB1 (McGeer et al., 1988; Payton et al., 2006; Mansouri et al., 2015; Zhang et al., 2022b). The gene discussed is HLA-DRB1; the disease is Alzheimer disease.