We stratified glioma patients into distinct subgroups based on gender, WHO grades, IDH status, 1p/19q status, MGMT promotor status, tumor stage, chemotherapy and radiotherapy, and observed the prognostic value of the reactive astrocyte score as a continuous variable in TCGA and CGGA datasets (Figures 6A,B). The gene discussed is MGMT; the disease is central nervous system cancer.