Bulk tumor sample sequencing data showed that the high level of TARA infiltration was tightly associated with tumor malignancy factors, such as WHO IV grade, wild-type IDH, mesenchymal subtype, unmethylated MGMT and wild-type ATRX. Meanwhile, recurrent glioma patients maintained a higher level of TARAs than primary glioma patients. Here, MGMT is linked to central nervous system cancer.