ESR2 and endometriosis: Related studies have shown that SKG1 not only has anti-apoptotic effects, but also can regulate the expression of the pro-apoptotic factor FOXO3a (Brunet et al., 2001; Zhang et al., 2001; Leong et al., 2003) Diana Monsivais et al. (Monsivais et al., 2016) verified SGK1 is a transcriptional target of ERβ upregulation in endometrial tissue which promotes the survival of endometriosis stromal cells.