Sapkota et al. identified five novel loci (FN1, CCDC170, ESR1, SYNE1 and FSHB) significantly associated with endometriosis risk through a meta-analysis concluding 11 genome-wide association case-control data sets, which included 17,045 endometriosis cases and 191,596 controls. This evidence concerns the gene ESR1 and endometriosis.