In the analysis of probiotic LGG in the treatment of mice with hepatic fibrosis induced by bile duct ligation and multidrug resistance protein 2 gene knockout, it is concluded that the therapeutic effect of LGG is to suppression of BAs de novo synthesis by upregulating intestinal FXR-FGF19 signal transduction, enhance the levels of Firmicutes and Actinomycetes with BSH activity, increase the excretion of BAs from feces, to prevent excessive liver injury and fibrosis caused by excessive toxic hepatic bile acids (Liu et al., 2020). Here, NR1H4 is linked to Hepatic fibrosis.