The destruction of the intestinal barrier in cirrhosis includes the reduction of the secretion of antibacterial peptides by intestinal Paneth cell, such as α- Defensin, especially α- Defensin 5 and 7, which have been proved in human small intestinal tissues and experimental models of decompensated cirrhosis (Kaliannan, 2018). This evidence concerns the gene DEFA5 and Cirrhosis.