Two cohort studies from the US (Veterans Aging Cohort and North American AIDS Cohort Collaboration on Research and Design [NA-ACCORD]) and two metanalyses, all including participants before the year 2013, have shown that CD4 counts < 200 cells/μL were associated with increased CV risk, including incident myocardial infarction (aHR 2.02; 95% CI, 1.42–2.88), ischemic stroke (aHR 1.66; 95% CI, 1.30–2.12), and peripheral artery disease (HR, 1.91; 95% CI, 1.71–2.13) (16–20). This evidence concerns the gene CD4 and peripheral arterial disease.